Response from Tanley et al. to Crystallography and chemistry should always go together: a cautionary tale of protein complexes with cisplatin and carboplatin.
نویسندگان
چکیده
School of Chemistry, Faculty of Engineering and Physical Sciences, University of Manchester, Brunswick Street, Manchester M13 9PL, England, Department of Biology, University of Konstanz, 78457 Konstanz, Germany, Crystal and Structural Chemistry, Bijvoet Center for Biomolecular Research, Faculty of Science, Utrecht University, Padualaan 8, 3584 CH Utrecht, The Netherlands, and Manchester Institute of Biotechnology (MIB), University of Manchester, 131 Princess Street, Manchester M1 7DN, England. *Correspondence e-mail: [email protected] ISSN 1399-0047
منابع مشابه
Responses to Crystallography and chemistry should always go together: a cautionary tale of protein complexes with cisplatin and carboplatin.
Responses to Crystallography and chemistry should always go together: a cautionary tale of protein complexes with cisplatin and carboplatin In this issue of Acta Cryst. D, Shabalin et al. (2015) critique and re-evaluate dozens of crystal structures in the PDB in which proteins are bound to the platinum compounds cisplatin or carboplatin. Investigators whose structures were critiqued were contac...
متن کاملCrystallography and chemistry should always go together: a cautionary tale of protein complexes with cisplatin and carboplatin.
The anticancer activity of platinum-containing drugs such as cisplatin and carboplatin is considered to primarily arise from their interactions with nucleic acids; nevertheless, these drugs, or the products of their hydrolysis, also bind to proteins, potentially leading to the known side effects of the treatments. Here, over 40 crystal structures deposited in the Protein Data Bank (PDB) of cisp...
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Platinum-based anticancer drugs are chemotherapeutic agents to treat cancer. Carboplatin (cis diammine cyclobutane dicarboxylate platinum (II)) is a second generation drug that has less toxic than cisplatin, allowing for high dosages. In the first stage, 1,3-Cyclobutane dicarboxylic acid, a key intermediate for the preparation of carboplatin, have been synthesized in good yields using diffe...
متن کاملHypersensitivity and cross-reactivity to cisplatin and carboplatin.
Cisplatin was the first of the platinum drugs. Second-generation platinum derivative was carboplatin that its efficacy in the treatment of many malignancies is equal to cisplatin, and its toxicity profile is more favorable. Here we report on a 50-year-old woman with a history of cervix cancer who developed a severe hypersensitivity reaction (HSR) to carboplatin. She was admitted to the emergenc...
متن کاملExperiences with archived raw diffraction images data: capturing cisplatin after chemical conversion of carboplatin in high salt conditions for a protein crystal
The archiving of raw diffraction images data is the focus of an IUCr Diffraction Data Deposition Working Group (see http://forums.iucr.org/). Experience in archiving and sharing of raw diffraction images data in collaboration between Manchester and Utrecht Universities, studying the binding of the important anti-cancer agents, cisplatin and carboplatin to histidine in a protein, has recently be...
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عنوان ژورنال:
- Acta crystallographica. Section D, Biological crystallography
دوره 71 Pt 9 شماره
صفحات -
تاریخ انتشار 2015